The naturally derived actives of Grapefruit stimulate the formation of Phase I and Phase II Enzymes, which strongly support the outward transfer and later destruction of toxins and chemicals from skin cells. Cayoma Grapefruit is an extract of the fruit and the seeds, containing different bioflavonoids. Hesperetin and Naringenin, the aglycones of the flavanone glycosides Hesperidin and Naringin are naturally present in Grapefruits. Hesperetin and Naringenin protect the DNA against the effects of UV-damage and oxidative stress. The Bioflavonoids are active against the formation of AGE (advanced glycation end products) and they reduce the formation of ROS significantly. Cayoma Grapefruit can be used in a range of skin care applications and is effective at low concentration levels.